Promethazine can be an H1 receptor blocking agent. Together with its antihistaminic motion, it offers clinically useful sedative and antiemetic consequences.

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Promethazine ought to be used cautiously in people with cardiovascular disease or with impairment of liver perform.

This can be associated with a lessen in efficacy, and in certain sufferers, may perhaps lead to signals and symptoms of opioid withdrawal.

When provided concomitantly with Promethazine HCl Oral Resolution, the dose of barbiturates really should be minimized by at the least a person-50 %, and the dose of narcotics should be reduced by one-quarter to at least one-50 percent. Dosage need to be individualized. Abnormal amounts of Promethazine HCl relative to the narcotic may perhaps bring on restlessness and motor hyperactivity while in the individual with ache; these symptoms usually vanish with adequate Charge of the ache.

Head Personal injury And Increased Intracranial Pressure: The respiratory-depressant effects of narcotic analgesics and their capacity to elevate cerebrospinal fluid pressure might be markedly exaggerated inside the presence of head damage, intracranial lesions or perhaps a preexisting increase in intracranial pressure.

Thanks to identical pharmacologic Houses, it is reasonable to assume similar possibility with concomitant utilization of opioid cough medications and benzodiazepines, other CNS depressants, or alcohol.

One example is, a lot of described scenarios of Loss of life occurred in the write-up-operative period of time adhering to tonsillectomy and/or adenoidectomy, and plenty of of the children experienced evidence of being extremely-fast metabolizers of codeine. Moreover, children with obstructive snooze apnea who are addressed with codeine for put up-tonsillectomy and/or adenoidectomy discomfort may be specially sensitive to its respiratory depressant outcome. Due to the hazard of daily life-threatening respiratory depression and death:

Promethazine is really an H1 receptor blocking agent. Along with its antihistaminic action, it offers clinically useful sedative and antiemetic results.

The following adverse reactions happen to be identified all through medical reports, inside the literature, or in the course of publish-acceptance utilization of codeine and/or promethazine.

INDICATIONS AND Utilization Promethazine HCl and Codeine Phosphate Oral Option is a mix of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for your short term reduction of cough and higher respiratory indications connected with allergy or perhaps the prevalent chilly in people eighteen decades of age and older. (one)

The mix of promethazine hydrochloride and website codeine phosphate is contraindicated in pediatric individuals a lot less than six yrs of age, mainly because the combination might result in fatal respiratory depression Within this age population (see WARNINGS Box Warning and Use in Pediatric Individuals).

Codeine was not mutagenic in the in vitro bacterial reverse mutation assay or clastogenic during the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.

Keep away from using Promethazine HCl and Codeine Phosphate Oral Option in adolescents twelve to 18 a long time of age who produce other hazard aspects that will increase their sensitivity towards the respiratory depressant outcomes of codeine. Hazard factors contain ailments associated with hypoventilation, for example postoperative standing, obstructive snooze apnea, weight problems, intense pulmonary disease, neuromuscular illness, and concomitant use of other medicines that result in respiratory melancholy.